| Game Name | System |
|---|
| Sega Rally Championship - DX | MAME |
| Sega Rally Championship - DX (Revision A) | MAME |
| Sega Rally Championship - TWIN/DX (Revision B) | MAME |
| Sega Rally Championship - TWIN/DX (Revision C) | MAME |
| Sega Ski Super G | MAME |
| Sega Sonic Cosmo Fighter | MAME |
| Sega Strike Fighter (Rev A) | MAME |
| Sega Strike Fighter (Rev A, no training mode) | MAME |
| Sega System SP (Spider) BIOS | MAME |
| Sega Tetris | MAME |
| Sega Touring Car Championship | MAME |
| Sega Touring Car Championship (Revision A) | MAME |
| Sega Touring Car Championship (Revision B) | MAME |
| Sega Water Ski (Japan, Revision A) | MAME |
| SegaSonic Popcorn Shop (Rev B) | MAME |
| SegaSonic The Hedgehog (Japan, prototype) | MAME |
| SegaSonic The Hedgehog (Japan, rev. C) | MAME |
| Sei Senshi Amatelass | MAME |
| Seibu Cup Soccer (set 1) | MAME |
| Seibu Cup Soccer (set 2) | MAME |
| Seibu Cup Soccer (set 3) | MAME |
| Seibu Cup Soccer :Selection: (bootleg, set 1) | MAME |
| Seibu Cup Soccer :Selection: (bootleg, set 2) | MAME |
| Seibu Cup Soccer :Selection: (bootleg, set 3) | MAME |
| Seibu Cup Soccer :Selection: (set 1) | MAME |
| Seibu Cup Soccer :Selection: (set 2) | MAME |
| Seicross | MAME |
| Seiha (Japan 870725) | MAME |
| Seiha [BET] (Japan 870723) | MAME |
| Seimei-Kantei-Meimei-Ki Cult Name | MAME |
| Seishun Scandal (315-5132, Japan) | MAME |
| Sel Feena | MAME |
| Select (Union) (MPU4) | MAME |
| Select-A-Game: Baseball 4 | MAME |
| Select-A-Game: Pinball | MAME |
| Select-A-Game: Space Invader 2 | MAME |
| Selection (Version 40.02TMB, set 1) | MAME |
| Selection (Version 40.02TMB, set 2) | MAME |
| Sen Jing - Guardian Storm (Japan) | MAME |
| Sen-Know (Japan) | MAME |
| Sengeki Striker (Asia) | MAME |
| Sengeki Striker (Japan) | MAME |
| Sengoku / Sengoku Denshou (NGH-017, US) | MAME |
| Sengoku / Sengoku Denshou (NGM-017 ~ NGH-017) | MAME |
| Sengoku 2 / Sengoku Denshou 2 | MAME |
| Sengoku 3 / Sengoku Densho 2001 | MAME |
| Sengoku Ace (Japan, set 1) | MAME |
| Sengoku Ace (Japan, set 2) | MAME |
| Sengoku Basara X Cross | MAME |
| Sengoku Blade: Sengoku Ace Episode II / Tengai | MAME |
| Sengoku Mahjong [BET] (Japan) | MAME |
| Senjou no Ookami | MAME |
| Senjou no Ookami II (Japan 900302) | MAME |
| Senjyo | MAME |
| Senko No Ronde (Japan) (GDL-0030) | MAME |
| Senko No Ronde (Japan, Rev A) (GDL-0030A) | MAME |
| Senko No Ronde Special (Export, Japan) (GDL-0038) | MAME |
| Senkyu (Japan set 1) | MAME |
| Senkyu (Japan set 2) | MAME |
| Sensory 9 Playmatic 'S' | MAME |
| Sensory Chess Challenger 12-B | MAME |
| Sensory Chess Challenger 9 | MAME |
| Sensory Chess Challenger 9 (rev. B) | MAME |
| Sente Diagnostic Cartridge | MAME |
| Seven Deadly Spins (Barcrest) (MPU5) | MAME |
| Seven's Above (Project) (PROCONN) | MAME |
| Sevens & Melons (Project) (PROCONN) | MAME |
| Sex Appeal (Version 6.02) | MAME |
| Sex Triv | MAME |
| Sexual Trivia (Version 1.02SB, set 1) | MAME |
| Sexual Trivia (Version 1.02SB, set 2) | MAME |
| Sexy Boom | MAME |
| Sexy Gal (Japan 850501 SXG 1-00) | MAME |
| Sexy Parodius (ver AAA) | MAME |
| Sexy Parodius (ver JAA) | MAME |
| Shackled (US) | MAME |
| Shadow Dancer (Japan) | MAME |
| Shadow Dancer (Mega-Tech) | MAME |
| Shadow Dancer (US) | MAME |
| Shadow Dancer (World) | MAME |
| Shadow Dancer (bootleg, set 1) | MAME |
| Shadow Dancer (bootleg, set 2) | MAME |
| Shadow Fighters | MAME |
| Shadow Force (Japan, Version 2) | MAME |
| Shadow Force (US, Version 2) | MAME |
| Shadow Force (World, Version 3) | MAME |
| Shadow Warriors (World, set 1) | MAME |
| Shadow Warriors (World, set 2) | MAME |
| Shadowland (YD3) | MAME |
| Shakatto Tambourine (Rev B) (GDS-0002B) | MAME |
| Shakatto Tambourine Cho Powerup Chu (2K1 AUT) (GDS-0016) | MAME |
| Shakatto Tambourine Motto Norinori Shinkyoku Tsuika (2K1 SPR) (GDS-0013) | MAME |
| Shake Rattle Roll (Mazooma) (Scorpion 4) (Top Box) | MAME |
| Shake Rattle Roll Arcade (Mazooma) (Scorpion 4) (set 1) | MAME |
| Shake Rattle Roll Arcade (Mazooma) (Scorpion 4) (set 2) | MAME |
| Shake Rattle Roll Arcade (Mazooma) (Scorpion 4) (set 3) | MAME |
| Shake Rattle Roll Arcade (Mazooma) (Scorpion 4) (set 4) | MAME |
| Shake Rattle Roll Arcade (Mazooma) (Scorpion 4) (set 5) | MAME |
| Shake Rattle Roll Arcade (Mazooma) (Scorpion 4) (set 6) | MAME |
| Shake Rattle Roll Arcade (Mazooma) (Scorpion 4) (set 7) | MAME |
