| Game Name | System |
|---|
| Scramble (Reben S.A. Spanish bootleg) | MAME |
| Scramble (Recreativos Franco, Spanish bootleg) | MAME |
| Scramble (Stern Electronics set 1) | MAME |
| Scramble (Stern Electronics set 2) | MAME |
| Scramble (Tomy) | MAME |
| Scramble (bootleg on Galaxian hardware) | MAME |
| Scramble (bootleg) | MAME |
| Scramble (bootleg?) | MAME |
| Scramble Spirits (Japan, Floppy DS3-5000-02-REV-A Based) | MAME |
| Scramble Spirits (World, Floppy Based) | MAME |
| Scramble Spirits (World, Floppy Based, FD1094 317-0058-02c) | MAME |
| Scrambled Egg | MAME |
| Screamin Demon (Maygay) (EPOCH) (SCDE 1.0, set 3) | MAME |
| Screamin Demon (Maygay) (EPOCH) (SCDE 1.0, set 4) | MAME |
| Screamin Demon (Maygay) (EPOCH) (SCDE 2.0, set 1) | MAME |
| Screamin Demon (Maygay) (EPOCH) (SCDE 2.0, set 2) | MAME |
| Screen Play (Maygay, MV1 Video, SA5-082) | MAME |
| Screen Play (Maygay, MV1 Video, SA5-083) | MAME |
| Screen Play (Maygay, MV1 Video, ver. 1.9, Isle of Man, set 1) | MAME |
| Screen Play (Maygay, MV1 Video, ver. 1.9, Isle of Man, set 2) | MAME |
| Screen Play (Maygay, MV1 Video, ver. 1.9, set 1) | MAME |
| Screen Play (Maygay, MV1 Video, ver. 1.9, set 2) | MAME |
| Screen Play (Maygay, MV1 Video, ver. 4.0) | MAME |
| Screen Play (Maygay, MV1 Video, ver. ?.?) | MAME |
| Screw Loose (prototype) | MAME |
| Screwin' Around (Global) (MPU4, v0.5) | MAME |
| Screwin' Around (Global) (MPU4, v0.7) | MAME |
| Screwin' Around (Global) (MPU4, v0.8) | MAME |
| Screwin' Around (Global) (MPU4, v0.8) (Protocol) | MAME |
| Scrum Try (DECO Cassette) (US) (set 1) | MAME |
| Scrum Try (DECO Cassette) (US) (set 2) | MAME |
| Scud Hammer | MAME |
| Scud Race Deluxe (Japan) | MAME |
| Scud Race Plus | MAME |
| Scud Race Plus (Revision A) | MAME |
| Scud Race Twin (Australia) | MAME |
| Scud Race Twin (Export) | MAME |
| Se Gye Hweng Dan Ultra Champion (Korea) | MAME |
| Sea Bass Fishing (JUET 971110 V0.001) | MAME |
| Sea Battle (set 1) | MAME |
| Sea Battle (set 2) | MAME |
| Sea Fighter Poseidon | MAME |
| Sea Hunter Penguin | MAME |
| Sea Wolf (set 1) | MAME |
| Sea Wolf (set 2) | MAME |
| Sea Wolf II | MAME |
| Sea World (Version 1.6E Dual) | MAME |
| Sea World (Version 1.6R CGA) | MAME |
| Seal The Deal - Jackpot Carnival (0251029, US) | MAME |
| Search Eye (English / Korean / Japanese / Italian) | MAME |
| Search Eye (English / Korean) | MAME |
| Search Eye Plus V2.0 | MAME |
| Search Light (Maygay) (M1A/B) (set 1) | MAME |
| Search Light (Maygay) (M1A/B) (set 2) | MAME |
| Search Light (Maygay) (M1A/B) (set 3) | MAME |
| Seawitch | MAME |
| Second Chance | MAME |
| Second Love (Japan 861201) | MAME |
| Secret 7s (Bwb) (MPU5) (set 1) | MAME |
| Secret 7s (Bwb) (MPU5) (set 2) | MAME |
| Secret Agent (Japan revision 2) | MAME |
| Secret Agent (Maygay) (EPOCH) (1.3, set 3) | MAME |
| Secret Agent (Maygay) (EPOCH) (1.5, set 1) | MAME |
| Secret Agent (Maygay) (EPOCH) (1.5, set 2) | MAME |
| Secret Agent (Nova) (MPU4) | MAME |
| Secret Agent (World revision 3) | MAME |
| Secret Agent (bootleg) | MAME |
| Secret Castle (v1) (Electrocoin) | MAME |
| Secret Service (2.6 alternate sound) | MAME |
| Secret Service (2.6) | MAME |
| Secret Service (4.2 alternate sound) | MAME |
| Section 16 (Mazooma) (Scorpion 4) (set 1) | MAME |
| Section 16 (Mazooma) (Scorpion 4) (set 2) | MAME |
| Section Z (set 1) | MAME |
| Section Z (set 2) | MAME |
| Sector Zone | MAME |
| See See Find Out | MAME |
| Sega Bass Fishing (Japan) | MAME |
| Sega Bass Fishing Challenge | MAME |
| Sega Bass Fishing Challenge Version A | MAME |
| Sega Bass Fishing Deluxe (Japan) | MAME |
| Sega CD (USA, NTSC) | MAME |
| Sega CD 2 (USA, NTSC) | MAME |
| Sega CD with 32X (USA, NTSC) | MAME |
| Sega Clay Challenge | MAME |
| Sega Club Golf 2006 Next Tours (Rev A) (GDX-0018A) | MAME |
| Sega Lindbergh Bios | MAME |
| Sega Marine Fishing | MAME |
| Sega Network Taisen Mahjong MJ 2 (Rev C) (GDX-0006C) | MAME |
| Sega Network Taisen Mahjong MJ 2 (Rev F) (GDX-0006F) | MAME |
| Sega Network Taisen Mahjong MJ 2 (Rev G) (GDX-0006G) | MAME |
| Sega Network Taisen Mahjong MJ 3 (Rev D) (GDX-0017D) | MAME |
| Sega Network Taisen Mahjong MJ 3 (Rev F) (GDX-0017F) | MAME |
| Sega Network Taisen Mahjong MJ 3 Evolution (Rev B) (GDX-0021B) | MAME |
| Sega Ninja (315-5102) | MAME |
| Sega Ninja (315-5113) | MAME |
| Sega Ninja (not encrypted) | MAME |
| Sega Race-TV (Export) | MAME |
| Sega Rally 2 | MAME |
| Sega Rally 2 DX | MAME |
