| Game Name | System |
|---|
| Same! Same! Same! (Japan) | Genesis |
| Sampras Tennis 96 (Europe) (J-Cart) | Genesis |
| Samurai Shodown (Europe) | Genesis |
| Samurai Shodown (USA) | Genesis |
| Samurai Spirits (Japan) | Genesis |
| Sangokushi II (Japan) | Genesis |
| Sangokushi III (Japan) | Genesis |
| Sangokushi Retsuden - Ransei no Eiyuutachi (Japan) | Genesis |
| Sanguozhi Liezhuan - Luanshi Qunying (China) | Genesis |
| Sanguozhi V (China) (Unl) | Genesis |
| Saturday Night Slammasters (Europe) | Genesis |
| Saturday Night Slammasters (USA) | Genesis |
| Scooby Doo Mystery (USA) | Genesis |
| Scrabble (Europe) (Proto) | Genesis |
| SeaQuest DSV (Europe) | Genesis |
| SeaQuest DSV (USA) | Genesis |
| Second Samurai (Europe) | Genesis |
| Sega Sports 1 (Europe) | Genesis |
| Sega Top Five (Brazil) | Genesis |
| Senjou no Ookami II ~ Mercs (World) | Genesis |
| Sensible Soccer (Europe) (En,Fr,De,It) | Genesis |
| Sensible Soccer (Europe) (En,Fr,De,It) (Beta) | Genesis |
| Sensible Soccer - International Edition (Europe) (En,Fr,De,It) | Genesis |
| Sesame Street Counting Cafe (USA) | Genesis |
| Shadow Blasters (USA) | Genesis |
| Shadow Dancer - The Secret of Shinobi (World) | Genesis |
| Shadow of the Beast (USA, Europe) | Genesis |
| Shadow of the Beast - Mashou no Okite (Japan) | Genesis |
| Shadow of the Beast II (USA, Europe) | Genesis |
| Shadowrun (Japan) | Genesis |
| Shadowrun (USA) | Genesis |
| Shadowrun (USA) [Hack by Magus77 v2.2] (Conversion Mod) | Genesis |
| Shane Warne Cricket (Europe) | Genesis |
| Shanghai II - Dragon's Eye (USA) | Genesis |
| Shanghai II - Dragon's Eye (USA) (Beta) | Genesis |
| Shaq Fu (USA, Europe) | Genesis |
| Shijie Zhiye Bangqiu Zhengba Sail 94 (China) (Unl) | Genesis |
| Shijou Saidai no Soukoban (Japan) | Genesis |
| Shikinjoh (Japan) | Genesis |
| Shin Souseiki Ragnacenty (Japan) | Genesis |
| Shining Force (USA) | Genesis |
| Shining Force (USA) (Beta) | Genesis |
| Shining Force - Kamigami no Isan (Japan) | Genesis |
| Shining Force II (Europe) | Genesis |
| Shining Force II (USA) | Genesis |
| Shining Force II (USA) [Hack by Obob v1.01] (Challenge Mode) | Genesis |
| Shining Force II - Koe no Fuuin (Japan) | Genesis |
| Shining and the Darkness (Japan) | Genesis |
| Shining in the Darkness (Brazil) | Genesis |
| Shining in the Darkness (USA, Europe) | Genesis |
| Shinobi III - Return of the Ninja Master (Europe) | Genesis |
| Shinobi III - Return of the Ninja Master (USA) | Genesis |
| Shiten Myouou (Japan) | Genesis |
| Shougi no Hoshi (Japan) | Genesis |
| Shove It! ...The Warehouse Game (USA) | Genesis |
| Show do Milhao (Brazil) | Genesis |
| Show do Milhao Volume 2 (Brazil) | Genesis |
| Show do Milhao Volume 2 (Brazil) (Alt) | Genesis |
| Shura no Mon (Japan) | Genesis |
| Side Pocket (Europe) | Genesis |
| Side Pocket (Japan) | Genesis |
| Side Pocket (USA) | Genesis |
| Simpsons, The - Bart Vs The Space Mutants (USA, Europe) | Genesis |
| Simpsons, The - Bart Vs The Space Mutants (USA, Europe) (Rev A) | Genesis |
| Simpsons, The - Bart's Nightmare (USA, Europe) | Genesis |
| Skeleton Krew (Europe) | Genesis |
| Skeleton Krew (USA) | Genesis |
| Skitchin (USA, Europe) | Genesis |
| Slap Fight MD (Japan) | Genesis |
| Slaughter Sport (USA) | Genesis |
| Slime World (Japan) | Genesis |
| Smurfs Travel the World, The (Europe) (En,Fr,De,Es) | Genesis |
| Smurfs, The (Europe) (En,Fr,De,Es,It) | Genesis |
| Snake Rattle n' Roll (Europe) | Genesis |
| Snow Bros. - Nick & Tom (Japan) | Genesis |
| Socket (USA) | Genesis |
| Sol-Deace (USA) | Genesis |
| Soldiers of Fortune (USA) | Genesis |
| Soleil (Europe) | Genesis |
| Soleil (France) | Genesis |
| Soleil (Germany) | Genesis |
| Soleil (Japan) (Beta) | Genesis |
| Soleil (Spain) | Genesis |
| Sonic & Knuckles (World) | Genesis |
| Sonic & Knuckles + Sonic the Hedgehog (World) | Genesis |
| Sonic & Knuckles + Sonic the Hedgehog 2 (World) | Genesis |
| Sonic & Knuckles + Sonic the Hedgehog 2 (World) [Hack by Hachelle-Bee v1.8] (Long Version) | Genesis |
| Sonic & Knuckles + Sonic the Hedgehog 3 (World) | Genesis |
| Sonic 3D Blast (USA) (Beta) | Genesis |
| Sonic 3D Blast (USA, Europe) | Genesis |
| Sonic Classics (USA, Europe) (v1.1) | Genesis |
| Sonic Compilation (Europe) | Genesis |
| Sonic Crackers (Japan) (Proto) | Genesis |
| Sonic Eraser (Japan) (SegaNet) [En by D v1.0] | Genesis |
| Sonic Spinball (Europe) | Genesis |
| Sonic Spinball (Japan) | Genesis |
| Sonic Spinball (USA) | Genesis |
| Sonic Spinball (USA) (Alt) | Genesis |
| Sonic Spinball (USA) (Beta) | Genesis |
| Sonic the Hedgehog (Japan) | Genesis |
