| Game Name | System |
|---|
| Shrek's Carnival Craze - Party Games (U)(XenoPhobia) | NDS |
| Shugo Chara! - Amu no Nijiiro Chara Change (J)(BAHAMUT) | NDS |
| Shugo Chara! 3-tsu no Tamagoto Koisuru Joker (J)(Independent) | NDS |
| Shugo Chara! Norinori! Chara-Nari Zumu (JP)(Independent) | NDS |
| Shunkan Puzz Loop (J)(SCZ) | NDS |
| Shuwa no Mori - Shokyuu Hen (JP)(BAHAMUT) | NDS |
| Sid Meier's Civilization Revolution (E)(XenoPhobia) | NDS |
| Sid Meier's Civilization Revolution (JP)(Caravan) | NDS |
| Sid Meier's Civilization Revolution (U)(XenoPhobia) | NDS |
| Sideswiped (US)(Suxxors) | NDS |
| Sight Training (E)(XenoPhobia) | NDS |
| Sigma Harmonics (J)(Independent) | NDS |
| Signal (J) | NDS |
| Silke - Pixelines Lillesoester - Hoensefoedder og Guleroedder (E) | NDS |
| Silke - Pixelines Lillesoester - Syng, Leg og Laer (E) | NDS |
| Silly Bandz - Play the Craze (U) | NDS |
| SimAnimals (EU)(M10)(EXiMiUS) | NDS |
| SimAnimals (JP)(M2)(Caravan) | NDS |
| SimAnimals (KS)(NEREiD) | NDS |
| SimAnimals (U)(Micronauts) | NDS |
| SimAnimals - Africa (EU)(M5) | NDS |
| SimAnimals - Africa (J) | NDS |
| SimAnimals - Africa (US)(M6) | NDS |
| SimCity - Creator (E)(SQUiRE) | NDS |
| SimCity - Creator (K)(CoolPoint) | NDS |
| SimCity - Creator (U)(XenoPhobia) | NDS |
| SimCity DS (E)(FireX) | NDS |
| SimCity DS (J)(WRG) | NDS |
| SimCity DS (K)(Independent) | NDS |
| SimCity DS (U)(iNSTEON) | NDS |
| SimCity DS (v01) (JP)(BAHAMUT) | NDS |
| SimCity DS 2 - Kodai Kara Mirai e Tsuduku Machi (J)(Caravan) | NDS |
| Simple DS Series Vol. 1 - The Mahjong (J)(SCZ) | NDS |
| Simple DS Series Vol. 10 - The Doko Demo Kanji Quiz (J)(WRG) | NDS |
| Simple DS Series Vol. 11 - Mou Ichido Kayoeru - The Otona no Shougakkou (J)(WRG) | NDS |
| Simple DS Series Vol. 12 - The Party Unou Quiz (J)(WRG) | NDS |
| Simple DS Series Vol. 14 - The Jidousha Kyoushuujo DS (J)(Caravan) | NDS |
| Simple DS Series Vol. 16 - The Sagasou - Fushigi na Konchuu no Mori (J)(Caravan) | NDS |
| Simple DS Series Vol. 18 - The Soukou Kihei Gun Ground (J)(Independent) | NDS |
| Simple DS Series Vol. 2 - The Billiards (v01) (J)(Trashman) | NDS |
| Simple DS Series Vol. 20 - The Senkan (J)(Caravan) | NDS |
| Simple DS Series Vol. 22 - The Zero-Yon Shinya (J)(Undutchable) | NDS |
| Simple DS Series Vol. 23 - The Puzzle Quest - Agaria no Kishi (J)(Chikan) | NDS |
| Simple DS Series Vol. 23 - The Puzzle Quest - Agaria no Kishi (v01) (JP)(High Road) | NDS |
| Simple DS Series Vol. 24 - The Sensha (J)(Sir VG) | NDS |
| Simple DS Series Vol. 25 - The Koushounin (J)(Independent) | NDS |
| Simple DS Series Vol. 26 - The Quiz 30000-Mon (J)(Navarac) | NDS |
| Simple DS Series Vol. 27 - The Misshitsu kara no Dasshutsu - The Suiri Bangai-hen (J)(6rz) | NDS |
| Simple DS Series Vol. 28 - The Illust Puzzle & Suuji Puzzle 2 (J)(6rz) | NDS |
| Simple DS Series Vol. 29 - The Sports Daishuugou (J)(6rz) | NDS |
| Simple DS Series Vol. 3 - The Mushitori Oukoku (J)(WRG) | NDS |
| Simple DS Series Vol. 30 - The Table Game (J)(6rz) | NDS |
| Simple DS Series Vol. 31 - The Chou-Dangan!! Custom Sensha (J)(Caravan) | NDS |
| Simple DS Series Vol. 32 - The Zombie Crisis (J)(6rz) | NDS |
| Simple DS Series Vol. 33 - The Crossword & Kanji Puzzle (J)(Independent) | NDS |
| Simple DS Series Vol. 34 - The Haisha-San (J)(Independent) | NDS |
| Simple DS Series Vol. 35 - The Genshijin (J)(Caravan) | NDS |
| Simple DS Series Vol. 36 - ALC de Mi ni Tsuku! TOEIC Test - Bunpou Tokkun Hen (JP)(2CH) | NDS |
| Simple DS Series Vol. 38 - ALC de Manabu! TOEIC Test - Hajimete Hen (J)(NRP) | NDS |
| Simple DS Series Vol. 39 - The Shouboutai (J)(High Road) | NDS |
| Simple DS Series Vol. 4 - The Block Kuzushi (J)(SCZ) | NDS |
| Simple DS Series Vol. 4 - The Block Kuzushi (v01) (JP)(High Road) | NDS |
| Simple DS Series Vol. 40 - The Gekai (J)(High Road) | NDS |
| Simple DS Series Vol. 41 - The Bakudan Shorihan (J)(Caravan) | NDS |
| Simple DS Series Vol. 42 - The Haioku Byoutou (J)(Caravan) | NDS |
| Simple DS Series Vol. 43 - The Host Shiyouze! DX Knight King (JP)(BAHAMUT) | NDS |
| Simple DS Series Vol. 44 - The Gal Mahjong (J)(High Road) | NDS |
| Simple DS Series Vol. 45 - The Misshitsu Kara no Dasshutsu 2 (J)(Independent) | NDS |
| Simple DS Series Vol. 46 - The Hikyou Tankentai (JP)(Caravan) | NDS |
| Simple DS Series Vol. 47 - The Suiri - Shinshou 2009 (JP)(MHS) | NDS |
| Simple DS Series Vol. 48 - The Saibanin - 1-Tsu no Shinjitsu, 6-Tsu no Kotae (JP)(BAHAMUT) | NDS |
| Simple DS Series Vol. 5 - The Trump (J)(WRG) | NDS |
| Simple DS Series Vol. 6 - The Party Game (J)(SCZ) | NDS |
| Simple DS Series Vol. 7 - The Illust Puzzle & Suuji Puzzle (J)(WRG) | NDS |
| Simple DS Series Vol. 7 - The Illust Puzzle & Suuji Puzzle (v01) (JP)(High Road) | NDS |
| Simple DS Series Vol. 8 - The Kanshikikan (J)(WRG) | NDS |
| Simple DS Series Vol. 9 - Atama no Yokunaru - The Me no Training (J)(WRG) | NDS |
| Simpson - Il Videogioco, I (I)(Puppa) | NDS |
| Simpsons El Videojuego, Los (S)(EXiMiUS) | NDS |
| Simpsons Game, The (E)(XenoPhobia) | NDS |
| Simpsons Game, The (U)(Micronauts) | NDS |
| Simpsons das Spiel, Die (G)(sUppLeX) | NDS |
| Simpsons le Jeu, Les (F)(EXiMiUS) | NDS |
| Sims 2 - Apartment Pets, The (E)(DSRP) | NDS |
| Sims 2 - Apartment Pets, The (U)(XenoPhobia) | NDS |
| Sims 2 - Castaway, The (E)(EXiMiUS) | NDS |
| Sims 2 - Castaway, The (K)(EXiMiUS) | NDS |
| Sims 2 - Castaway, The (U)(XenoPhobia) | NDS |
| Sims 2 - Hachamecha Hotel Life, The (J)(Mode 7) | NDS |
| Sims 2 - Pet Wan Nyan Life, The (J)(WRG) | NDS |
| Sims 2 - Pets, The (E)(Legacy) | NDS |
| Sims 2 - Pets, The (U)(Sir VG) | NDS |
| Sims 2 - Survival, The (J)(Chikan) | NDS |
| Sims 2, The (E)(Trashman) | NDS |
| Sims 2, The (U)(Mode 7) | NDS |
| Sims 3, The (DSi Enhanced) (E) | NDS |
| Sims 3, The (DSi Enhanced) (U) | NDS |
| Six Flags - Fun Park (U)(Independent) | NDS |
| Skate It (E)(XenoPhobia) | NDS |
| Skate It (U)(XenoPhobia) | NDS |
